Wondering about the best wager among all 16 NFL matchups in Week 1? Our selection, in terms of the point spreads, is Packers +1. But see below, because we have lots more tips, and that could lead to parlay opportunities.

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Best Week 1 Spread Bets

Pick: Green Bay +1 vs. Chicago

  • Matchup: Green Bay Packers at Chicago Bears
  • Projected Favorite & Spread: Green Bay by 6.4 points
  • Time: 4:25 PM ET
  • Date: September 10
  • TV Channel: FOX
  • Live Stream: Watch this game on Fubo

Pick: Cincinnati -2.5 vs. Cleveland

  • Matchup: Cincinnati Bengals at Cleveland Browns
  • Projected Favorite & Spread: Cincinnati by 8.8 points
  • Time: 1:00 PM ET
  • Date: September 10
  • TV Channel: CBS
  • Live Stream: Watch this game on Fubo

Pick: San Francisco -2.5 vs. Pittsburgh

  • Matchup: San Francisco 49ers at Pittsburgh Steelers
  • Projected Favorite & Spread: San Francisco by 4.6 points
  • Time: 1:00 PM ET
  • Date: September 10
  • TV Channel: FOX
  • Live Stream: Watch this game on Fubo

Take advantage of these best bet suggestions and bet on any game with BetMGM!

Best Week 1 Total Bets

Over 45 - Philadelphia vs. New England

  • Matchup: Philadelphia Eagles at New England Patriots
  • Projected Total: 45.3 points
  • Time: 4:25 PM ET
  • Date: September 10
  • TV Channel: CBS
  • Live Stream: Watch this game on Fubo

Under 53.5 - Detroit vs. Kansas City

  • Matchup: Detroit Lions at Kansas City Chiefs
  • Projected Total: 51.6 points
  • Time: 8:20 PM ET
  • Date: September 7
  • TV Channel: NBC
  • Live Stream: Watch this game on Fubo

Under 46.5 - Buffalo vs. New York

  • Matchup: Buffalo Bills at New York Jets
  • Projected Total: 41.4 points
  • Time: 8:15 PM ET
  • Date: September 11
  • TV Channel: ABC/ESPN
  • Live Stream: Watch this game on Fubo

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